Search results for " Cardiopulmonary Bypass"

showing 3 items of 3 documents

Anaesthetic-related neuroprotection: intravenous or inhalational agents?

2010

In designing the anaesthetic plan for patients undergoing surgery, the choice of anaesthetic agent may often appear irrelevant and the best results obtained by the use of a technique or a drug with which the anaesthesia care provider is familiar. Nevertheless, in those surgical procedures (cardiopulmonary bypass, carotid surgery and cerebral aneurysm surgery) and clinical situations (subarachnoid haemorrhage, stroke, brain trauma and postcardiac arrest resuscitation) where protecting the CNS is a priority, the choice of anaesthetic drug assumes a fundamental role. Treating patients with a neuroprotective agent may be a consideration in improving overall neurological outcome. Therefore, a cl…

Central Nervous SystemTime FactorsNeuroprotective AgentIntravenouNeuroprotectionSevofluraneBrain IschemiaDesfluranePharmacotherapyadministration /&/ dosage/pharmacologyBrain InjurieAdministration InhalationAdministration; Inhalation Anesthesia; Intravenous Anesthetics; administration /&/ dosage/pharmacology Animals Brain Injuries Brain Ischemia Cardiopulmonary Bypass Central Nervous System; drug effects Clinical Trials as Topic Craniotomy Humans Inhalation; drug effects Neuroprotective Agents; administration /&/ dosage/pharmacology Rats Time FactorsMedicineAnimalsHumansPharmacology (medical)AnesthesiaAdverse effectStrokeAnestheticsClinical Trials as TopicAnaesthetic neuroprotectionCardiopulmonary Bypassbusiness.industryAnimalCardiopulmonary BypaSettore MED/27 - NeurochirurgiaAnestheticdrug effectmedicine.diseaseRatsPsychiatry and Mental healthNeuroprotective AgentsIsofluraneInhalationAnesthesiaBrain Injuriesdrug effectsAnestheticAdministrationAnesthesia IntravenousRatNeurology (clinical)businessIntravenousCraniotomymedicine.drugHuman
researchProduct

What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies

2016

Background. Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. Methods. A systematic literature review identified eight studies of which seven fulfilled criteria for metaanalysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long…

Heart Valve Diseases030204 cardiovascular system & hematologyGlobal HealthWMD weighted mean differencelaw.inventionPostoperative Complications0302 clinical medicineRisk FactorslawMitral valveCPB cardiopulmonary bypaStrokeHeart Valve Prosthesis ImplantationMedicine (all)Abbreviations and Acronyms AF atrial fibrillation; CI confidence interval; CPB cardiopulmonary bypass; MIMVS minimally invasive mitral valve surgery; OR odds ratio; PRC packed red cells; ST sternotomy; WMD weighted mean difference; Global Health; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Minimally Invasive Surgical Procedures; Mitral Valve; Postoperative Complications; Risk Factors; Survival Rate; Observational Studies as Topic; Risk Assessment; Cardiology and Cardiovascular Medicine; Surgery; Pulmonary and Respiratory Medicine; Medicine (all)Atrial fibrillationSurvival RateHeart Valve DiseaseObservational Studies as Topicmedicine.anatomical_structureCardiologyMitral ValveCardiology and Cardiovascular MedicineHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyAbbreviations and Acronyms AF atrial fibrillationSubgroup analysisRisk Assessment03 medical and health sciencesST sternotomyInternal medicinePRC packed red cellmedicineCardiopulmonary bypassHumansMinimally Invasive Surgical ProceduresSurvival ratebusiness.industryCI confidence intervalRisk FactorMinimally Invasive Surgical ProcedureOdds ratioOR odds ratiomedicine.diseaseConfidence intervalSurgeryMIMVS minimally invasive mitral valve surgery030228 respiratory systemSurgeryPostoperative ComplicationbusinessThe Annals of Thoracic Surgery
researchProduct

Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs

2004

Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide ( CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinical…

Sus scrofaMyocardial IschemiaApoptosisCardiotonic AgentsBiochemistrylaw.inventionchemistry.chemical_compoundAdenosine Triphosphateischemia reperfusion; heart arrest; apoptosis; hypoxia; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Apoptosis; Carbon Monoxide; Cardiotonic Agents; Edema; Electric Countershock; Energy Metabolism; Female; Guanosine Triphosphate; Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes Cardiac; NAD; NADP; Oxidation-Reduction; Sus scrofa; Cardiopulmonary BypasslawEdemaEdemaMyocytes CardiacCarbon MonoxideCardiopulmonary BypassMED/04 - PATOLOGIA GENERALEHeartCardiac surgeryAdenosine DiphosphateAnesthesiaCardiologyFemaleGuanosine Triphosphatemedicine.symptomCardiacOxidation-ReductionBiotechnologymedicine.drugischemia reperfusion; heart arrest; apoptosis; hypoxiaAdenosine monophosphatemedicine.medical_specialtyCardiotonic AgentsElectric CountershockMyocardial Reperfusion InjuryPhosphocreatineInternal medicineGeneticsmedicineCardiopulmonary bypassischemia reperfusionAnimalsMolecular BiologyMyocytesbusiness.industryhypoxiaNADAdenosineapoptosiAdenosine MonophosphateAdenosine diphosphatechemistryEnergy MetabolismbusinessNADPheart arrest
researchProduct